A list of common skin disorders and conditions where Collagen Induction Therapy (CIT) (aka: Dermal Needling or Micro-needling) shows excellent results:
· Thin Skin
· Loss of adhesion & resiliency
· Premature ageing
· Epidermal density & strength
· Lax skin
· UV damage
· Stretch Marks
· Hair restoration
How CIT improves… Lax Skin and Wrinkles
What went wrong?
· Keratinocyte damage = impaired signals to fibloblasts
· Deterioration of collagen & elastin fibrils
· Loss of structural integrity
· Increased levels of elastin (actinic elastosis)
· Loss of glycosaminoglycans (GAGs)
· Loss of adhesion (dermal-epidermal junction)
What are some causes?
· Chronological and mitochondrial aging
· Cellular senescence
· Glycation – sugar molecules (fructose or glucose) bond to proteins or lipids without the controlling action of an enzyme, leading to advanced glycation end products (AGE’s), which cause inflammation. Abnormal cross-linking results in damage to the collagen and elastin. Glycation CANNOT be reversed!
· UV irradiation
· Oxidative stress (radical exposure), which causes lipid peroxidation
· Repeated mechanical stress (frowning)
· Rapid weight loss
· Connective tissue disorders
How does CIT correct lax skin and wrinkles?
Increases the availability of cell nutrients and the triggering of the wound healing cascade brings platelets, fibroblasts, epithelial, and immune cells together to facilitate wound healing. A complex signaling system, made up of predominately of growth factors and the cytokines released by them, exists between these cells.
Rapid re-epithelialization leads to earlier restoration of normal cell-to-cell communication, especially between keratinocytes and fibroblasts; thus, negating the inflammatory cascades abd allowing fibroblasts differentiation that produces a physiological process of increased GAG production, and consequently more collagen. In addition, myofibroblasts produce a tightening effect through myofibril contraction using a mechanism similar to that in smooth muscle cells.
Source: The Concise Guide to Dermal Needling - Expanded Medical Edition by Dr. Lance Setterfield, M/D., 2013, pages 50-51.
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