Would taking a supplement that was high in Hyaluronic Acid (HA) stimulate the fibroblast enough to make more collagen type III?
I doubt it; however by supplementing the supporting glycosaminoglycans I could see the benefit in taking a supplement that contained Hyaluronic Acid if only to lengthen and protect the life of existing collagen fibrils.
Will taking glucosamine help build collagen?
Because glucosamine is a precursor for glycosaminoglycans and GAGs are a major component of the dermis, I would say that yes it is probably worth trying.
The benefit of glucosamine sulfate is likely the result of a number of effects including its anti-inflammatory activity and the stimulation of the synthesis of proteoglycans.
Would Hydrolysed Collagen stimulate the fibroblast enough to make more collagen type III?
The only benefit that I can see from using Hydrolysed Collagen as a supplement would be to obtain the amino acid content, but again the target is more of joints and cartilage (type II) not collagen found within the loose connective tissue of the dermis. (Type III)
Fibroblast Nutritional Requirements
There are a number of factors that will ensure the formation of healthy strong collagen.
Key Amino acids (proline & glycine)
Silicon allied with magnesium and calcium
Growth factors and Hormones
Zinc is a co factor
Iron is a co factor
Essential Fatty Acids are required for all cell functions and healthy cell membranes
If you're like me, you've been frustrated dealing with hyperpigmentation... You may have tried all the latest skin potions and procedures only to find little or no improvement or worse yet, the condition worsens... The reason why hyperpigmentation is so hard to treat is that the melanocyte is influenced by so many factors and usually it is not just one thing that went awry but many. When any of the following "directors" or signalers are overstimulated the result is the overproduction of pigment.
Source: The Concise Guide to Dermal Needling. Cell Function. page. 48-49, 96-97
Not All Collagen is Created Equal - Why Collagen Induction Therapy Produces Natural Collagen NOT Scar Collagen
In any anti-aging situation , growth factors need to be stimulated by some means. Typically this is accomplished through controlled wounding. Several different types of growth factors are released according to the type of wound incurred. Growth factors are responsible for orchestrating and regulating cellular function and repair after injury. An ideal skin rejuvenation wounding or treatment would both improve the penetration of any active ingredient and wake up the fibroblast.
Unfortunately most rejuvenation treatments rely on dramatically invasive chemical peels, light or radio frequency to burn the skin, which leads to the release of TGF-B1 and TGF-B2 (transforming growth factors), TIMP-1, and Heat Shock Protein 47. These generate a fibrotic response that promotes scar collagen (thick, parallel oriented bundles.)
By contrast collagen induction therapy or dermal needling results in increased TGF-B, FGF-7 (keratinocyte growth factor), and EGF (epidermal growth factor)which promotes natural collagen, with scarless wound healing.
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The introduction of retinoic acid and alpha hydroxy acids to skincare products marks the first time consumers saw immediate gratification in their anti-aging quest. It was a boom for esthetics, who now had clients setting up monthly visits to get their acid fix as part of their facial. The results were impressive-plump, taut skin with a reduced appearance of wrinkles. Who wouldn't be hooked.
The problem, however, is that these results are only temporary, and in the long run they actually damage the skin and cause it to age faster than it would if we didn't use the harsh products and techniques. The reason is that when we apply retinoic acid and alpha hydroxy acids to the skin, we are causing inflammation-and inflammation is bad for the skin. When you apply an acid to your face-and this applies to almost every acid, depending on the concentration-you immediately create trauma. This trauma results in swelling. Swelling makes wrinkles and fine lines look better, but only temporarily.
The other effect of these treatments is that they damage the epidermal barrier. The skin, being the intelligent defense mechanism that it is, sees this damage as an assault and seeks to fix the problem. In what is called an "emergency repair response," the skin rushes to repair the damaged epidermis, which speeds up the epidermal turnover rate. Unfortunately, many skincare experts assume that increased epidermal turnover is a good thing-evidence that the skin is returning to its youthful functioning-yet, this forced exfoliation is actually the skin's equivalent of a four-alarm fire.
Ben Johnson, MD "Transform Your Skin Naturally", 2010, Chapter 2, pp. 21-22.
In the early stages of wound healing the fibroblasts produce hyaluronic acid which helps stimulate cell renewal. In fact, one of the reasons fetal wound healing is scar-less is there is an abundance of hyaluronic acid. Studies have shown that hyaluronic acid applied topically during a wound dressing are associated with quicker healing and reduce scarring. Oral Glucosamine taken in adequate amounts during the first few days of surgery or trauma enhance hyaluronic acid production in the wound thus also promoting swifter healing with fewer complications related to scarring.
Three main factors create the environment in which acne can exist and ALL must be present for acne to occur.
1. Hormone Irregularities
2. Toxic Buildup
3. Genetics Tendencies
Or illustrated by this equation:
(Hormone Irregularities) x (Toxic Buildup) x (Genetic Tendencies) = Acne
Hormone Irregularities and Toxic Buildup
1. Congested liver, clogged and sluggish bowels
2. Nutrition deficiencies and dietary factors
3. Food allergies
5. Acid PH balance
7. Sleep disorders
*Test for Candida Overgrowth: In the morning before you eat or drink anything, make a large spit into a glass of water. Wait an hour. If you see legs or strings of saliva there is a moderate candida overgrowth, if the spit sinks to the bottom there is a more advanced candida overgrowth.
This is the most important factor and unfortunately cannot be controlled or deactivated.
The only genetic difference between acne sufferers and non-sufferers is that sufferers seem to have oil glands that are sensitive to even the slightest elevation in androgen levels. There could be other genetic factors that differentiate non-sufferers from sufferers such as the size of the oil gland, the skin type and other, unknown hereditary factors. At present, the most prominent genetic component in the formation of acne seems to be the over sensitivity of the oil gland receptors.*
Steps to Alleviate Acne
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Growth factors are compounds that act as chemical messengers between cells - turning on a variety of cellular activities. Growth factors play a role in cell division, new cell and blood vessel growth, and collagen and elastin production and distribution. Many growth factors used by the cosmetic industry are from bovine (cattle) sources in the form of colostrum polypeptides.
In an anti-aging situation, growth factors would need to be stimulated by some means. As an example, exercise induces insulin growth factors (IGF). Any stage of collagen replacement or repair requires some form of stimulation of a wound healing response. The ideal modalities are collagen induction therapy (CIT) and sonophoresis, both improve the penetration of any active ingredient and "wake up" the fibroblast.
Growth factors are predominately responsible for orchestrating and regulating cellular function and repair after injury. Most rejuvenation treatments rely on dramatically invasive chemical peels, light or radio frequency to burn the skin, which leads to release of TGF-B1 and TGF-B2 (transforming growth factors), TIMP-1, and Heat Shock Protein 47. These generate a fibrotic response that promotes scar collagen (thick, parallel orientated bundles). By contrast, collagen induction therapy results in increased TGF-B, FGF-7, and EGF which promotes natural collagen, with scarless wound healing. Understanding which growth factors produce positive effects, we can specifically target and manipulate cells to achieve desired results. Ideally, we want to limit the presence and duration of function of certain cells that contain deleterious growth factors and optimize those that result in a more natural, even tone and smooth healthy skin texture.
Source: The Concise Guide to Dermal Needling. Cell Function. page. 22, 24
Scientific research suggests that elevated levels of estrogen and progesterone can result in an increased growth of yeast in the body. Yeast is primarily housed in the digestive tract and may be culpable for as many as 30 percent of the acne cases seen on an annual basis. We can also increase yeast levels by eating sugar, which provides yeast populations with fodder to propagate. This propagation can then lead to imbalances in flora (healthy bacteria) that line our digestive tracts. This, in turn, allows for further yeast overgrowth.
The most common yeast population among Americans (relevant because of diet) is called Candida albicans, commonly referred to as Candida. Candida in associated with vaginal yeast infections and thrush. It may be a surprise but yeast infections originate in the intestine. When Candida levels fall out of balance, the yeast emits toxins that travel through the body via the body (via the blood stream) and result in a variety of physiological imbalances. If left unchecked, toxic yeast may rise up and disturb hormone production, impair immune function, and generally wreak havoc on many organs with the skin being the common victim.
The use of antibiotics to treat acne (used to counteract the bacteria that feed of the sebum in the skin) can cause an additional suppression of the immune system plus negatively affect digestive health which will inevitability exacerbate the development of acne. In my opinion, the colon and its related toxin build up is the primary source of acne. Suffice it to say that acne could be greatly reduce to changes in one's diet, colonics and detoxes (do your research and consult your physician as appropriate).
You may not know this...not all wrinkles are created equal. While wrinkles from sundamage and intrinsic aging can be improved, those from a process known as glycation cannot.
It is less widely known that blood sugar has an important bearing on the aging process. Unfortunately, in addition to being a vital cellular fuel, glucose is also a substance that can cause damage to cells and tissues by randomly reacting with proteins, DNA and other vital molecules.
In the process called non-enzymatic glycosylation or glycation, glucose molecules attach themselves to proteins, setting in motion a chain of chemical reactions that ends in the proteins binding together or crosslinking, thus altering their biological and structural roles. The process is slow but increases with time.
Advanced Glycosylation End products (AGEs), is the term given to Crosslinks of proteins like collagen and elastin, which seem to toughen tissues and may cause some of the deterioration associated with aging. AGEs have been linked to stiffening connective tissue (collagen), hardened arteries, clouded eyes, loss of nerve function, and less efficient kidneys. These are deficiencies that often accompany aging.
AGEs exert their harmful effects on two levels. Most obviously, they physically impair protein, DNA and lipids, altering their chemical properties. They also act as cellular signals, triggering a cascade of destructive events when they attach to their cellular binding sites.
The main binding site for AGEs is appropriately called RAGE (receptor for AGEs). The binding of AGEs to RAGE induces cellular activation and intracellular oxidative stress, AGE binding to RAGE tends to be self-amplifying, since the more AGEs bind to RAGE, the more RAGE binding sites develop. This creates a "positive feedback loop" leading to spreading waves of cellular activation and tissue damage.
One happy finding is that the body has its own defense system against crosslinking. Just as it has anti-oxidants to fight free-radical damage, it has other guardians, immune system cells called macrophages, that combat glycation.
Macrophages with special receptors for AGEs seek them out, engulf them, break them down, and eject them into the blood stream where they are filtered out by the kidneys and eliminated in urine. The only apparent drawback to this defense system is that it is not complete and levels of AGEs increase steadily with age. One reason is that kidney function tends to decline with advancing age.
Is there an answer to glycation?
Treatment is best started with prevention by diet control, reducing total calories, avoiding high sugar foods and not cooking at high temperatures. Supplements such as aminoguanidine, pyridoxamine, carnosine and benfotiamine are excellent glycation preventors.
Carnosine levels decline with age, and now that many people are cutting down on meat - the main dietary source of carnosine - supplementation becomes expecially important. Expect to see carnosine in the 'new generation' of actives of the future.
Beautymag Online, Glycosylation and the Ageing Process
Peter T. Pugliese, MD, April 14, 2008, from the April 2008 issue of Skin Inc. magazine.
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